A Genealogical Interpretation of Linkage Disequilibrium
نویسندگان
چکیده
منابع مشابه
A genealogical interpretation of linkage disequilibrium.
The degree of association between alleles at different loci, or linkage disequilibrium, is widely used to infer details of evolutionary processes. Here I explore how associations between alleles relate to properties of the underlying genealogy of sequences. Under the neutral, infinite-sites assumption I show that there is a direct correspondence between the covariance in coalescence times at di...
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1. Abstract 2. Introduction 3. Models and methods 3.1. Haplotype block characterization 3.2. Measure of haplotype block LD 3.3. Test statistic and power calculation 3.4. Population genetic model of haplotype block 4. Results 4.1. Haplotype block LD measure 4.2. Power of the haplotype block LD mapping 4.3. Mapping 5. Discussion 6. Appendix 6.1. Appendix A 6.2. Appendix B 6.3. Appendix C 7. Refer...
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ژورنال
عنوان ژورنال: Genetics
سال: 2002
ISSN: 1943-2631
DOI: 10.1093/genetics/162.2.987